منابع مشابه
Two-player Knock ’em Down
We analyze the two-player game of Knock ’em Down, asymptotically as the number of tokens to be knocked down becomes large. Optimal play requires mixed strategies with deviations of order √ n from the naive law-of-large numbers allocation.
متن کاملRapid conditional knock-down–knock-in system for mammalian cells
RNA interference (RNAi) is a powerful tool to analyze gene function in mammalian cells. However, the interpretation of RNAi knock-down phenotypes can be hampered by off-target effects or compound phenotypes, as many proteins combine multiple functions within one molecule and coordinate the assembly of multimolecular complexes. Replacing the endogenous protein with ectopic wild-type or mutant fo...
متن کاملShRNA-mediated knock-down of CD200 using the self-assembled nanoparticle-forming derivative of polyethylenimine
Objective(s): ShRNA-mediated silencing strategy is considered to be a potent therapeutic approach. The present study aimed to assess the ability of the previously prepared polyethylenimine (PEI) derivative for the shRNA knock-down of the CD200 gene on the cells obtained from the patients with chronic lymphocytic leukemia (CLL). Materials and Methods: Since there are several investigations...
متن کاملOptimal Token Allocations in Solitaire Knock 'm Down
In the game Knock ’m Down, tokens are placed in N bins. At each step of the game, a bin is chosen at random according to a fixed probability distribution. If a token remains in that bin, it is removed. When all the tokens have been removed, the player is done. In the solitaire version of this game, the goal is to minimize the expected number of moves needed to remove all the tokens. Here we pre...
متن کاملCRISPR/Cas9-Mediated Gene Knock-Down in Post-Mitotic Neurons
The prokaryotic adaptive immune system CRISPR/Cas9 has recently been adapted for genome editing in eukaryotic cells. This technique allows for sequence-specific induction of double-strand breaks in genomic DNA of individual cells, effectively resulting in knock-out of targeted genes. It thus promises to be an ideal candidate for application in neuroscience where constitutive genetic modificatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: WAHANA
سال: 2018
ISSN: 2654-4954,0853-4403
DOI: 10.36456/wahana.v70i2.1740